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B
Resistance to insulin
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C
Malnutrition
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D
Obesity
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Solution
The correct option is A Loss of pancreatic beta cells
Diabetes mellitus occurs due to hyposecretion of insulin hormone. Insulin is a peptide or proteinaceous hormone secreted from the β (beta) cells of islets of Langerhans of pancreas. Insulin acts on hepatocytes and adipocytes and increases the uptake of cellular glucose and its utilisation. Thus, it decreases blood glucose level. Deficiency of insulin leads to high blood glucose level.
So, the correct answer is 'Loss of pancreatic beta cells'.