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Question

Ketone bodies are formed in

A
Liver
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B
Spleen
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C
Kidney
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D
Heart
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Solution

The correct option is A Liver
Ketone bodies are made up of two molecules, acetoacetate and -hydroxybutyrate. Ketone bodies are formed mostly in the liver. The first stage of ketogenesis consists of oxidation. The resulting acetyl-CoA is turned into acetoacetate. The subsequent reduction of acetoacetate to hydroxybutyrate occurs in the liver by releasing the surplus hydrogen that accumulates during oxidation. Both acetoacetate and hydroxybutyrate are released into the circulation.
Thus, the correct answer is option A.

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