Question

Klinefelter's syndrome has the following phenotype and karyotype.

• A. Male and $47$, XXY
• B. Female and $47$, XXX
• C. Male and $47$, XYY
• D. Female and $46$, X

Answer 1

Answer: (A)

Male and $47$, XXY

Klinefelter syndrome, also known as 47, XXY or XXY is a chromosomal condition that affects males. Typically, people have two sex chromosomes in each cell: females have two X chromosomes (46, XX), and males have one X and one Y chromosome (46, XY). Klinefelter syndrome results from the presence of one extra copy of the X chromosome in each cell (47, XXY).

In this condition, there is an interference with male sexual development, often preventing the testes from functioning normally and reducing the levels of testosterone. Symptoms are more severe if three or more X chromosomes are present.

So, the answer is A.