Question

Krebs cycle begins with ________.

• A. Condensation of acetyl-CoA with OAA and $H_{2}O$ to yield citric acid
• B. Conversion of OAA into citric acid through oxidation of $NA{D}^{+}$
• C. Oxidative decarboxylation of pyruvic acid to acetyl CoA
• D. Cleavage of succinyl CoA into succinic acid and coenzyme A.

Answer 1

The correct option is A Condensation of acetyl-CoA with OAA and $H_{2}O$ to yield citric acid

The Krebs cycle starts with condensation of acetyl group with oxaloacetic acid (OAA) and water to yield citric acid. This reaction is catalysed by the enzyme citrate synthase and a molecule of CoA is released.