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Question 33
Lack of oxygen in muscles often leads to cramps among cricketers. This happens due to

(a) Conversion of pyruvate to ethanol
(b) Conversion of pyruvate to glucose
(c) Non-conversion of glucose to pyruvate
(d) Conversion of pyruvate to lactic acid

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Solution

(d) Conversion of pyruvate to lactic acid

The burning sensation in muscles during difficult exercise can be attributed to the production of hydrogen ions during a shift to anaerobic glycolysis as oxygen is converted to carbon dioxide by aerobic respiration faster than the body can replenish it. When sufficient oxygen is not present in the muscle cells for further oxidation of pyruvate and NADH produced in glycolysis, NAD+ is regenerated from NADH by reduction of pyruvate to lactic acid. Pyruvate is converted to lactic acid by the enzyme lactate dehydrogenase.


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