Question

Lactic acid causes fatigue in muscles due to

• A. Sensitivity of neuromuscular junction
• B. Acidity
• C. Binding of muscle calcium
• D. Causing expulsion of cations

Answer 1

The correct option is A Sensitivity of neuromuscular junction

• Lactic acid is formed and accumulated in the muscle under conditions of high energy demand, rapid fluctuations of the energy requirement and insufficient supply of O2.
• During exercise, there is a progressive reduction in the ability to produce muscle forces processes within the nervous system, as well as within the muscles contribute to this fatigue.
• Finally, the small-diameter muscle afferents that increase firing with exercise and fatigue. Hence, Lactic acid causes fatigue in muscles due to the Sensitivity of neuromuscular junction.

So, the correct answer is 'Sensitivity of neuromuscular junction'.