Suppose that m is an integer root of x4+ax3−bx2+cxd=0. As d≠0, we have m≠0.
Suppose now that m > 0.
Then m4+am3=bm2−cmd>0 and hence m>a≥d.
If m < 0, then writing n=m>0 we have n4+an3−bn2+cnd=n4+n2(anb)+(cnd)>0, a contradiction.
This proves that the given polynomial has no integer roots