Level of follicle stimulating hormone (FSH) during infancy and adulthood is the same but spermatogenesis is seen only during adulthood. mRNA levels coding for FSH receptors are also found to be same in testis of both age groups. Which of the following investigations will clarify this paradox a little more?

Culture testcular cells and add to see testosterone production.

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Culture testicular cells and add testosterone to see comparative rise in FSH mRNA from both age groups.

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Culture testicular cells and FSH to see comparative rise in cAMP production by both age groups.

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Add both LH and FSH to testicular cells and evaluate cAMP production.

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Solution

The correct option is A Culture testcular cells and add to see testosterone production.
In males, FSH and LH are secreted by hypothalamus. FSH stimulates Sertoli cells of the testes to secrete androgen binding protein (ABP) that concentrates testosterone in seminiferous tubules. LH stimulates interstitial cells (leydig's cells) of the testes to secrete androgens testosterone. Androgens stimulate germinal epithelium to undergo spermatogenesis.

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Similar questions

Q. Testosterone is a steroid hormone produced by all vertebrate animals and, in humans and other mammals, it is secreted in large amounts by the testes of males and to a much lesser extent, the ovaries of females. In adult males, testosterone plays a key role in the development of reproductive organs and it promotes the secondary sexual characteristics of body and facial hair, increased muscle and bone mass, and a deep voice. Testosterone, like all hormones, works via long distance signaling and is regulated by other hormones as illustrated below:

Figure 1:

Testosterone regulation by cooperation between the hypothalamus, pituitary, and testicular endocrine glands. The major regulatory hormones involved are luteinizing hormone (LH), follicle-stimulating hormone (FSH) and gonadotropin-releasing hormone (GnRH).

When testosterone levels are low, gonadotropin-releasing hormone (GnRH) is released by the hypothalamus, which in turn stimulates the pituitary gland to release FSH and LH. FSH and LH then stimulate the testis to produce testosterone.
How is homeostasis achieved when testosterone levels begin to rise?

Q. Assertion :FSH is also Known as an interstitial cell-stimulating hormone. Reason: It is because of the fact that FSH stimulates the interstitial cells of the testis.

Q. Both LH and FSH attain a peak level

Q. Peaks of LH and FSH production occur during

Identify the correct match of column $I, I I$ and $I I I$ .

Column - $I$		Column - $I I$		Column - $I I I$
sertoli cells	a	LH	i	spermatogenesis
leydig's cells	b	inhibin	ii	formation of the ovarian follicle
anterior pituitary	c	testosterone	iii	suppress FSH
ovary	d	estrogen	iv	ovulation

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