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Question

Lysis of foreign cells is mediated through

A
IgM only
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B
IgA only
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C
IgM and IgG
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D
IgD and IgE
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Solution

The correct option is B IgM and IgG
  • Immunoglobulin M (IgM) is one of several forms of the antibody that are produced by vertebrates. IgM is the largest antibody, and it is the first antibody to appear in the response to initial exposure to an antigen. IgM can bind to complement component and activate the classical pathway, leading to opsonization of antigens and cytolysis (lysis of foreign cells).
  • IgG is the most common type of antibody found in blood circulation. IgG molecules are created and released by plasma B cells. Coating of IgG on pathogen surfaces (known as opsonization) allows their recognition and ingestion by phagocytic immune cells leading to the lysis of foreign cells.
So, the correct answer is 'IgM and IgG'.

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