Question

Major Histocompatibility Complex (MHC) is present on

• A. only antigen presenting cells
• B. B and T lymphocytes
• C. Macrophages and dendritic cells
• D. All nucleated cells

Answer 1

The correct option is D All nucleated cells

Major Histocompatibility complex (MHC) is a surface glycoprotein which is expressed on nearly all nucleated cells. MHC plays a pivotal role in the adaptive immune response. The main function of the MHC is to present antigen to T cells to discriminate between self and non-self tissues, and hence tissue matching during organ transplantation or grafting.

Antigen presenting cells (APCs) are the immune cells that mediate the cellular immune response by processing and presenting antigens for recognition by certain lymphocytes. Professional antigen presenting cells include dendritic cells, macrophages and B cells.