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Fast block to polyspermy – As the sperm head comes in contact with the fertilization cone, it cause opening of Na+ channels to cause depolarization of ovum membrane. This is called fast block to polyspermy.
Slow block to polyspermy – Ca2+ influx causes extrusion of cortical granules and zona reactions which make the zona pellucida impervious to second sperm by destroying sperm receptors.