Question

Mark the incorrect option in context to $O2$ binding to $Hb$.

• A. Higher $p{O}_2$
• B. Lower $pH$
• C. Lower $pC{O}_2$
• D. Lower temperature

Answer 1

The correct option is B Lower $pH$

Lower $pH$ :

Lower $pH$ means acidic $pH$, which occurs due to high $pC{O}_2$. At lower $pH$, the concentration of hydrogen ions is more. Greater concentration of hydrogen ions stabilizes hemoglobin in the deoxygenated $T$-state. This reduces the affinity of hemoglobin for oxygen and lowers the formation of oxyhemoglobin.

Low temperature :

Low temperature favours the binding of $O_2$ to hemoglobin while higher temperature indicates higher heat generated which favors $O_2$ unloading and delivery to tissues.

Lower $pC{O}_2$ :

In alveoli, lower $pC{O}_2$ favours the binding of oxygen to hemoglobin to form oxyhemoglobin.

Higher $p{O}_2$ :

High $p{O}_2$ favours the binding of oxygen with the hemoglobin and forms oxyhemoglobin.

Final answer : a. Lower $pH$