Match Column I and Column II regarding the clotting process:

$i)\Rightarrow a,~ii)\Rightarrow d,~iii)\Rightarrow c,~iv)\Rightarrow b, v)\Rightarrow e$

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$i)\Rightarrow d,~ii)\Rightarrow a,~iii)\Rightarrow b,~iv)\Rightarrow c, v)\Rightarrow e$

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$i)\Rightarrow e,~ii)\Rightarrow b,~iii)\Rightarrow d,~iv)\Rightarrow c, v)\Rightarrow a$

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$i)\Rightarrow b,~ii)\Rightarrow c,~iii)\Rightarrow a,~iv)\Rightarrow d, v)\Rightarrow e$

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Solution

The correct option is C
$i)\Rightarrow e,~ii)\Rightarrow b,~iii)\Rightarrow d,~iv)\Rightarrow c, v)\Rightarrow a$

When the blood vessels are damaged they attract platelets. The damaged endothelial cells express tissue factor. The tissue factor initiates a coagulation cascade. The end result of the cascade is the formation of an enzyme called prothrombinase.This prothrombinase cleaves prothrombin giving rise to thrombin.The platelets have specific thrombin receptors; the thrombin attaches to the platelets and form a weak plate plug. Thrombin acts on fibrinogen in the plasma and cleaves it to form insoluble fibrin strands.The insoluble fibrin strands are then stabilized to form a clot by fibrin stabilizing factor which is activated by thrombin.

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