Question

Match the column.

a	Sickle cell anaemia	$1$	Sex-linked
b	Colour blindness	$2$	Autosomal	$7$
c	Phenyl ketonuria	$3$	Autosomal chromosome	$11$
d	Cystic fibrosis	$4$	Autosomal chromosome	$4$
e	Huntigton's chorea	$5$	Autosomal chromosome	$12$

• A. a-$3$, b-$5$, c-$1$, d-$2$, e-$4$
• B. a-$3$, b-$1$, c-$5$, d-$2$, e-$4$
• C. a-$4$, b-$1$, c-$5$, d-$2$, e-$3$
• D. a-$5$, b-$1$, c-$2$, d-$3$, e-$4$
• E. a-$2$, b-$1$, c-$5$, d-$3$, e-$4$

Answer 1

Answer: (B)

a-$3$, b-$1$, c-$5$, d-$2$, e-$4$

• Genes responsible for the most common, inherited colour blindness are on the X chromosome.
• Sickle cell disease is caused by a mutation in the hemoglobin-Beta gene found on chromosome 11.
• PKU is an autosomal recessive disorder, caused by mutations in both alleles of the gene for phenylalanine hydroxylase (PAH), found on chromosome 12.
• Huntington's disease is a progressive brain disorder caused by a single defective gene on chromosome 4.
• Cystic fibrosis is an inherited disease caused by mutations (changes) in a gene on chromosome 7.

So, the correct answer is 'a-3, b-1, c-5, d-2, e-4'.