Question

Match the following.

Aversion Therapy/Antabuse Therapy	Action
(i) Disulfiram	(a) Calming effect, increased binding of the inhibitory neurotransmitter GABA to the GABA(A) receptor.
(ii) Emetine hydrochloride	(b) Produced from the roots of Carapichea ipecacuanha, patient start vomitting
(iii) Chlordiazepoxide	(c) Blood acetaldehyde concentrations are increased

• A. (i)-(c), (ii)-(a), (iii)-(b)
• B. (i)-(a), (ii)-(b), (iii)-(c)
• C. (i)-(b), (ii)-(c), (iii)-(a)
• D. (i)-(c), (ii)-(b), (iii)-(a)

Answer 1

The correct option is D (i)-(c), (ii)-(b), (iii)-(a)

Antabuse therapies for abuse include use of
(i)Disulfiram tablet is given to the patient. Now, if the patient drinks even small amount of alcohol, he suffers from nausea, vomiting, headache, flushing, palpitation, mental confusion etc. Hence, he avoids alcohol. This is because oxidation of alcohol is halted at aldehyde stage, causing increase in serum acetaldehyde levels.
(ii) Emetine hydrochloride injection is given to patient. Now, if the patient sees, smells or drinks alcohol, he starts vomiting. Hence, he starts hating alcohol. (Emetine hydrochloride is toxic, hence it is not used any more. It is obtained from roots of Carapichea ipecacuanha.
(iii) Chlordiazepoxide prevents withdrawal symptoms. It causes increased binding of the inhibitory neurotransmitter GABA( Gamma-Aminobutyric acid) to the GABA(A) receptor. It results in calming, sedative effect in the mammalian brain.