The correct option is A A - t, B - p, C - r, D - q
Antonie van Leeuwenhoek developed an interest in lens making and he was the first to observe and describe single-celled organisms using his handcrafted microscopes. So, option A matches with option t.
Edward Buchner was awarded Nobel prize for his work on cell-free extract of yeast cells. He named the enzyme that brought about the fermentation of sucrose as 'zymase'. So, option B matches with option p.
Selman Walksman is recognized as the discoverer of streptomycin. So, option C matches with option r.
Wilhelm His was anatomist, who invented the microtome. So, option D matches with option q.
Thus, the correct answer is option (A), 'A-t, B-p, C-r, D-q'.