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Question
Melanuria (black urine) is caused by abnormal catabolism of which of the following amino acid?
Melanuria (black urine) is caused by abnormal catabolism of which of the following amino acid?
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Solution
The correct option is B Tyrosine
Alkaptonuria is a genetic disorder which imparts inability to process the amino acids phenylalanine and tyrosine. Mutation in the HGD gene that codes for the enzyme homogentisate 1, 2-dioxygenase is the cause of this disorder. A person homozygous for mutated allele accumulates an intermediate substance called as homogentisic acid in the blood and tissues. Presence of homogentisic acid and its oxidized form alkapton in urine impart black colour to it. The correct answer is "B".
Alkaptonuria is a genetic disorder which imparts inability to process the amino acids phenylalanine and tyrosine. Mutation in the HGD gene that codes for the enzyme homogentisate 1, 2-dioxygenase is the cause of this disorder. A person homozygous for mutated allele accumulates an intermediate substance called as homogentisic acid in the blood and tissues. Presence of homogentisic acid and its oxidized form alkapton in urine impart black colour to it. The correct answer is "B".
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