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Question

Men with Klinefelter syndrome do not show barr body because

A
They can inactivate extra copy of chromosome
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B
They cannot activate the extra copy of chromosome
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C
They have linked genes
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D
All of the above
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Solution

The correct option is A They can inactivate extra copy of chromosome
During embryonic development, female inactivates one of the X chromosomes because if both the X chromosomes are genetically expressed simultaneously, then double the necessary genetic products will be made. This inactivated X chromosome is called a Barr body. Men with Klinefelter syndrome (47, XXY ) have a single Barr body but it is not seen because that extra copy of X chromosome is inactivated.

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