Cell-cell adhesion complexes known as adhering junctions (AJs) allow cells within tissue to respond to pressures, biochemical cues, and structural changes in their surroundings. AJs are constantly created and destroyed.
Adhering junctions are found in between epithelial cells and the small intestine.
It also helps in actin cytoskeleton modulation and intracellular signaling.
It plays an important transcriptional regulation.
It is a thick layer of proteins that lines the interior of the plasma membrane adhesins-fused microfilaments and membrane proteins of the cytoskeleton are where it attaches.