Meristematic cells have a prominent nucleus and a dense cytoplasm but lack a vacuole, this is so because meristematic cells have an ability to divide and form new cell. Vacuoles have a function of storing food and other nutrients that a cell might need to survive. But, there is no point in storing food and other nutrients when the cell has to divide.
They require energy for dividing ,and energy comes from the glucose they make .because they need energy frequently they do not have much food to store in,so they do not have vacuole and have a prominent and large nucleus .