MHCs are present as self antigens on all body cells except
A
RBCs
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B
WBCs
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C
Lymphocytes
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D
Tissue cells
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Solution
The correct option is A RBCs The major histocompatibility complex (MHC) is a collection of genes coding for MHC molecules found on the surface of all nucleated cells of the body. There are two classes of MHC molecules involved in adaptive immunity, MHC I and MHC II. MHC I molecules are found on all nucleated cells, they present normal self-antigens as well as abnormal or non-self pathogens to the effector T cells involved in cellular immunity. In contrast, MHC II molecules are only found on macrophages, dendritic cells, and Bcells; they present abnormal or non-self pathogen antigens for the initial activation of T cells.