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Question

Most biologists think that RNA was the first genetic material because:

A
RNA is single-stranded
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B
RNA is very stable
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C
Of the existence of ribozymes
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D
Both b and c
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Solution

The correct option is C Of the existence of ribozymes
RNA is a single-stranded molecule. It is not a very stable molecule as it has uracil as one of its nitrogenous bases. Uracil is less stable than thymine, the latter being the nitrogenous base of DNA. Another reason for its reduced stability is its ribose sugar which has reactive OH at 2' position of carbon.

RNA can also act as an enzyme by catalysing formation of peptide bond between two amino acids during translation in the ribosome. Such RNA’s are called ribozymes.
Existence of ribozymes (enzymes) suggests that catalytic RNA can catalyze a chemical reaction to copy itself in primitive organisms. Such a self-replicating RNA has the ability to pass genetic material from generation to generation, fulfilling the most important criteria for life.
So, the correct answer is option 'c'.

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