The correct option is C large population
The Hardy-Weinberg model describes and predicts genotype and allele frequencies in a non-evolving population. The model has five basic assumptions:
1. The population is large (i.e., there is no genetic drift)
2. There is no gene flow between populations, from migration or transfer of gametes
3. Mutations are negligible
4. Individuals are mating randomly
5. Natural selection is not operating on the population
Given these assumptions, a population’s genotype and allele frequencies will remain unchanged over successive generations and hence, Hardy Weinberg principle is applicable in a large population.