The correct option is C Emphysema
Emphysema, most commonly caused as a result of smoking, causes major damage to the alveoli. It reduces the surface area involved in gas exchange to a huge extent.
In asthma, the affected person's airways become inflamed, resulting in narrowing down of the air passages.
Pleurisy is the inflammation of the pleura (the double-layered membrane surrounding the lungs).
Pneumonia is an infection most commonly caused by microbes such as bacteria or viruses. It fills the alveoli with fluid, causing breathing difficulties. Hence, the most appropriate answer here is emphysema.