Name the site(s) of pyruvate synthesis. Also, write the chemical reaction wherein pyruvic acid dehydrogenase acts as a catalyst.

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Solution

Pyruvate is synthesized in the cytoplasm of the cell by the process of glycolysis. 1 molecule of glucose forms 2 molecules of pyruvate through a series of reactions.

Pyruvic acid dehydrogenase catayses the reaction in which pyruvate forms acetyl Co-A. It requires $N A D^{+}$ , Co-enzyme A and $M g^{2 +}$ ions for its activity. The reaction as follows

$Pyruvic acid + C o - A + N A D^{+} M g^{2 +} - -------------- \to Pyruvate Dehydrogenase A c e t y l C o - A + N A D H + H + + C O_{2} ↑$

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P y r u v i c a c i d + C o A + {N A D}^{+} M g^{2 +} - -------------- \to P y r u v a t e d e h y d r o g e n a s e A + B + N A D H + H^{+}

P y r u v a t e - ------- \to d e h y d r o g e n a s e A c e t y l C o A + C O_{2} + N a D H_{2}

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