Catecholamines is any of the various amines such as epinephrine, norepinephrine, and dopamine that are derived from tyrosine, and that function as hormones or neurotransmitters or both. Catecholamines help the body respond to stress or fright and prepare the body for "fight-or-flight" reactions. The adrenal glands make large amounts of catecholamines as a reaction to stress. Noradrenaline (norepinephrine), the main neurotransmitter of the sympathetic nervous system, is responsible for tonic and reflexive changes in cardiovascular tone. Adrenaline (epinephrine) is a key determinant of responses to metabolic or global challenges to homeostasis, such as glucoprivation, and of manifestations of emotional distress.