Question

Non-competitive inhibition often results in

• A. Change in enzyme structure
• B. Blocking of active site
• C. Non-synthesis of enzymes
• D. Non-availability of cofactor

Answer 1

The correct option is A Change in enzyme structure

Part of an enzyme where substrate molecules get attached is known as an active site. On attachment to the active site, the substrate is changed into the product. The active site has a residue which helps in the attachment of substrate. The substrate molecules form a temporary bond with the enzyme at the active site. A molecule similar to substrate competes with the substrate for the active site. Such molecules are known as an inhibitor.

In a non- competitive inhibition the inhibitor attaches to the enzyme at the site other than the active site. The inhibitor and the substrate bind to the enzyme at the same time at the different site which leads to conformational changes in the active site and prevents the attachment of substrate.

So, the correct answer is option A.