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Question

.............. of the eukaryotic chromosomes shorten with every cell replication.

A
Telomeres
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B
Centromeres
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C
Kinetochores
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D
Nucleosomes
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Solution

The correct option is D Telomeres
A telomere is a repeating DNA sequence (for example, TTAGGG) at the end of the body's chromosomes. The telomere can reach a length of 15,000 base pairs. Telomeres function by preventing chromosomes from losing base pair sequences at their ends. They also stop chromosomes from fusing to each other. However, each time a cell divides, some of the telomere is lost (usually 25-200 base pairs per division). When the telomere becomes too short, the chromosome reaches a "critical length" and can no longer replicate. This means that a cell becomes "old" and dies by a process called apoptosis.
Therefore, the correct answer is option A.

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