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Question

On stimulation of skeletal muscle, calcium is immediately made available for binding to troponin from

A
Blood
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B
Lymph
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C
Bone
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D
Sarcoplasmic reticulum
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Solution

The correct option is D Sarcoplasmic reticulum
  • A neural signal reaching this junction releases a neurotransmitter (Acetylcholine) which generates an action potential in the sarcolemma. This spreads through the muscle fibre and causes the release of calcium ions into the sarcoplasm from the sarcoplasmic reticulum.
  • Active sites for myosin are present on actin which are masked by troponin-C in resting state. When Ca++ level increases it leads to the binding of calcium with a subunit of troponin i.e Troponin-C on actin(thin) filaments and thereby remove the masking of active sites for myosin.
  • Hence on stimulation of skeletal muscle, calcium is immediately made available for binding to troponin from sarcoplasmic reticulum.
  • So, the correct answer is 'Sacroplasmic reticulum'.

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