On the basis of chemical nature of estradiol and progesterone are
Steroids
Tissue metabolism and physiological functions are regulated by hormones. On the basis of their chemical nature, hormones can be divided into groups.
(i) Peptide, polypeptide, protein hormones (e.g., insulin, glucagon, pituitary hormones, hypothalamic hormones, etc.)
(ii) Steroids (e.g., cortisol, testosterone, estradiol and progesterone)
(iii) Iodothyronines (thyroid hormones)
(iv) Amino-acid derivatives (e.g., epinephrine).
Hormones which interact with membrane-bound receptors normally do not enter the target cell, but generate second messengers (e.g., cyclic AMP, IP3, Ca++ etc) which in turn regulate cellular metabolism