Question

Optimum pH for activation of pepsinogen is

• A. $1.5-2$
• B. $6$
• C. $8$
• D. $10$

Answer 1

Answer: (A)

$1.5-2$

• Peptic or chief cells of gastric glands produce an inactive enzyme called pepsinogen.
• The proenzyme pepsinogen, on exposure to hydrochloric acid($pH1.5-2$), gets converted into the active enzyme pepsin, the proteolytic enzyme of the stomach.
• Hence Optimum pH for activation of pepsinogen is $1.5-2$.
• So, the correct answer is '$1.5-2$'.