Osteoporosis, an age-related disease of skeletal system, may occur due to

Decreased level of estrogen

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Accumulation of uric acid leading to inflammation of joints

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Immune disorder affecting neuromuscular junction leading to fatigue

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High concentration of

C a^{+ +}

and

N a^{+}

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Solution

The correct option is A Decreased level of estrogen
Dropping levels of estrogen during menopause can lead to osteoporosis and so it is, an age-related disease of the skeletal system.

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