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Question

Osteoporosis, an age-related disease of the skeletal system may occur due to


A

Decreased level of estrogen

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B

Accumulation of uric acid leading to inflammation of joints

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C

Immune disorder affecting neuromuscular junction leading to fatigue

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D

High concentration of Ca++ and Na+

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Solution

The correct option is A

Decreased level of estrogen


Estrogen helps to regulate the bone cells osteoblasts, which are responsible for building new bone. Low estrogen levels can lead to increased bone decay and osteoporosis. When estrogen levels drop after menopause in women, fewer cells are produced and bone is lost, but not replaced in aged individuals.
Gout is a painful condition that occurs when the bodily waste product uric acid is deposited as needle-like crystals in the joints.
The autoimmune disorder affecting neuromuscular junction leading to fatigue, weakening, and paralysis of skeletal muscle is myasthenia gravis.
Hypercalcemia is a condition in which the calcium level in your blood is above normal. Too much calcium in your blood can weaken your bones, create kidney stones.
In hypernatremia, the level of sodium in the blood is too high. Hypernatremia involves dehydration, which can have many causes, including not drinking enough fluids, diarrhea, kidney dysfunction, and diuretics.


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