Oxygen carrying capacity of haemoglobin is reduced in which of the following diseases?

Albinism

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Sickle-cell anaemia

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Optic neuropathy

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Down syndrome

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Solution

The correct option is B Sickle-cell anaemia
Sickle-cell anaemia is a genetic disorder. It arises due to the replacement of glutamic acid by valine at the sixth position of the haemoglobin chain. As a result, the shape of the RBC changes to sickle-shaped from biconcave. These RBCs cannot pass through the blood vessels and have a tendency to clot, resulting in anaemia. Clogged blood vessels reduces blood circulation due to which tissues becomes deprived of oxygen.

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The compound which forms a poisonous complex with haemoglobin and reduces the oxygen carrying capacity of haemoglobin is:

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