$P_{5} 0$ is the partial pressure of oxygen at which haemoglobin is 50% saturated. What will happen to the $P_{5} 0$ value if there is an increase in the partial pressure of Carbon dioxide and what effect will it have on the oxygen affinity of haemoglobin (Hb)?

$P_{5} 0$ value will decrease and the oxygen affinity of Hb will increase

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$P_{5} 0$ value will increase and the oxygen affinity of Hb will increase

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$P_{5} 0$ value will decrease and the oxygen affinity of Hb will decrease

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$P_{5} 0$ value will increase and the oxygen affinity of Hb will decrease

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Solution

The correct option is D
$P_{5} 0$ value will increase and the oxygen affinity of Hb will decrease

When the partial pressure of carbon dioxide increases, the oxygen Hb dissociation curve shifts towards the right resulting in the increase of $P_{5} 0$ value. Consequently, the oxygen affinity of Hb decreases because more Hb binds with carbon dioxide.

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P50 is the partial pressure of oxygen at which haemoglobin is 50% saturated. What will happen to theP50 value if there is an increase in the partial pressure of Carbon dioxide and what effect will it have on the oxygen affinity of haemoglobin (Hb)?

$P_{5} 0$ is the partial pressure of oxygen at which haemoglobin is 50% saturated. What will happen to the $P_{5} 0$ value if there is an increase in the partial pressure of Carbon dioxide and what effect will it have on the oxygen affinity of haemoglobin (Hb)?