What would be the situation if the mother is Rh(+ve) and foetus is Rh(-ve)?
and what is meant by anti - Rh antibodies?
What would be the situation if the mother is Rh(+ve) and foetus is Rh(-ve)?
and what is meant by anti - Rh antibodies?
Possibilities for the Rh status of child from Rh- father and Rh+mother .
If mother is homozygous for Rh+, then all childs will definitely be Rh+.
If mother is heterozygous for Rh+ then child can either be Rh+ or Rh- .
For Rh+child
Mother is Rh+ then having Rh+ blood of the fetus will not be foreign (antigen) so no antibodies will be produced against each other.
For Rh-child
If developing child is Rh- and mother is Rh+, then mother will recognize fetal blood as foreign molecule (antigen) and will produce antibodies against it that kill fetus, leading to stillbirth.
The anti Rh antibodies also called RhoGam are given to pregnant mother before and after the birth of their Rh(+) child. The anti-Rh antibody interacts with the Rh(+) cells before the cells react with the mother's B-cells to trigger a primary response. RhoGam is therefore called a blocking antibody.
Possibilities for the Rh status of child from Rh- father and Rh+mother .
If mother is homozygous for Rh+, then all childs will definitely be Rh+.
If mother is heterozygous for Rh+ then child can either be Rh+ or Rh- .
For Rh+child
Mother is Rh+ then having Rh+ blood of the fetus will not be foreign (antigen) so no antibodies will be produced against each other.
For Rh-child
If developing child is Rh- and mother is Rh+, then mother will recognize fetal blood as foreign molecule (antigen) and will produce antibodies against it that kill fetus, leading to stillbirth.
The anti Rh antibodies also called RhoGam are given to pregnant mother before and after the birth of their Rh(+) child. The anti-Rh antibody interacts with the Rh(+) cells before the cells react with the mother's B-cells to trigger a primary response. RhoGam is therefore called a blocking antibody.
