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Question

Parkinson's disease is caused due to lesion in

A
Corpus striatum
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B
RAS
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C
Limbic system
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D
Analysis centre of cerebrum
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Solution

The correct option is A Corpus striatum
Parkinson's disease is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain. Parkinson's disease results in loss of dopaminergic innervation to the striatum. Dopamine is a neurotransmitter responsible for transmitting signals between the substantia nigra and multiple brain regions. The connection between the substantia nigra and the corpus striatum is critical to producing smooth, purposeful movement. Loss of dopamine in this circuit results in abnormal nerve-firing patterns within the brain that cause impaired movement.

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