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Question

Pathogenicity of bacteria causing tuberculosis and leprosy is due to

A
Cholesterol
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B
Ergosterol
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C
Prostaglandins
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D
Glycerol
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E
Wax-D
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Solution

The correct option is C Wax-D
The cell wall structure of Mycobacterium tuberculosis deserves special attention, because it is unique among prokaryotes, and it is a major determinant of virulence for the bacterium. The cell wall complex contains peptidoglycan, but otherwise, it is composed of complex lipids. Over 60% of the mycobacterial cell wall is a lipid. The lipid fraction of MTB's cell wall consists of three major components, mycolic acids, cord factor and wax-D. Bacteria that cause tuberculosis and leprosy produce a wax (wax D), that repels ordinary laboratory stains and contributes to their pathogenicity.

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