Pepsinogen is activated by ________.

Chymotrypsin

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Trypsin

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HCl

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Pepsin

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Solution

The correct option is C HCl
The hormone gastrin and the vagus nerve trigger the discharge of both pepsinogen and HCl from the stomach filling when food is ingested. Hydrochloric acid creates an acidic environment, which allows pepsinogen to convert into active pepsin. Pepsinogen is initially activated by the $H^{+}$ ions.
So, the correct answer is option C.

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\begin{matrix} a) Pepsinogen is secreted by & I)Liver b) Trypsin is secreted by & II) Pancreas c) Bile is produced in & III) Gall bladder d) Bile is stored in & IV) Gastric glands \end{matrix}

how HCl activates pepsinogen?

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