Question

Pernicious anaemia is

• A. Low RBC count
• B. Death of WBC
• C. Inability of RBC maturation
• D. Destruction of young RBC

Answer 1

The correct option is C Inability of RBC maturation

Pernicious anaemia (PA) is an autoimmune disorder in which the body fails to make enough healthy red blood cells (RBCs). The body requires vitamin B${}_{12}$ and a type of protein called intrinsic factor (IF) to make red blood cells. Vitamin B${}_{12}$ deficiency produces a small number of overly large and ineffective RBCs called macrocytes. Because of their large size, these cells may not be able to leave the bone marrow and enter the bloodstream.