The correct option is D Amphetamine
Physical dependence refers to a state resulting from chronic use of a drug that has produced tolerance and where negative physical symptoms of withdrawal result from abrupt discontinuation or dosage reduction. Amphetamine is a potent CNS stimulant of the phenethylamine class that is used in the treatment of attention deficit hyperactivity disorder. Of the given options, opiates, cannabis and cocaine are all drugs and shows physical dependence.
So, the correct answer is option D.