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Question

Physiologically urea is produced by the action of an enzyme

A
Uricase
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B
Urease
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C
Arginase
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D
None
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Solution

The correct option is B Arginase

Urea is produced by the liver through urea cycle. It starts with the condensation of ammonium ion with bicarbonate ion which results the formation of carbamoyl phosphate in the presence of enzyme carbamoyl phos­phate synthase. Carbamoyl phosphate combines with ornithine to form citrulline in presence of enzyme citrulline synthase or ornithine transcarbamoylase. Citrulline diffuses into the cytosol. Citrulline combines with the amino acid aspartate and argininosuccinate catalyzed by the enzyme argininosuccinate synthase. The enzyme argininosuccinase acts reversibly to cleave arginino­succinate into arginine and fumarate. Arginine is lysed into ornithine and urea under the influence of the enzyme arginase. So the correct answer is “arginase”.


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