Question

Point mutation involves:

• A. Insertion
• B. Deletion
• C. Duplication
• D. Change in a single base pair

Answer 1

The correct option is D

Change in a single base pair

The correct option is D.

Explanation of the correct option:

1. A mutation is a sudden, stable, inheritable change in the genetic material of an organism.
2. Point mutation occurs due to a change in the single base pair of DNA.
3. Sickle cell anemia is caused due to a point mutation.
4. In it, glutamic acid is substituted by valine at the sixth position of the beta-globin chain of hemoglobin.

Explanation of the incorrect options:

Option A:

1. Insertion of a base pair of DNA is a frameshift mutation.
2. Example - Crohn's disease.

Option B:

1. Deletion of a base pair of DNA is a frameshift mutation.
2. Example - Cystic fibrosis.

Option C:

1. Duplication of one sex chromosome is called trisomy.
2. Duplication of a whole set of chromosomes is called polyploidy

Final answer: Point mutation involves a change in a single base pair.