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Question
Porphyrin of heme (hemoglobin) is synthesized by liver by combining acetic acid with the amino acid
Porphyrin of heme (hemoglobin) is synthesized by liver by combining acetic acid with the amino acid
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Solution
The correct option is D Glycine
The first step in the biosynthesis of porphyrin is the formation of -aminolevulinic acid (-ALA) by the reaction of the amino acid glycine with succinyl-CoA. Two molecules of -ALA are then combined by Porphobilinogen synthase to give Porphobilinogen (PBG), which contains a pyrrole ring. Four PBGs are then combined through deamination into Hydroxymethyl bilane (HMB), which is hydrolysed to form the circular tetrapyrrole Uroporphyrinogen III. This molecule undergoes a number of further modifications and the main end-product is Protoporphyrin IX. Then Protoporphyrin IX is combined with iron to form heme. One of the best-known porphyrins is heme, the pigment in red blood cells, a cofactor of the protein hemoglobin.
The first step in the biosynthesis of porphyrin is the formation of -aminolevulinic acid (-ALA) by the reaction of the amino acid glycine with succinyl-CoA. Two molecules of -ALA are then combined by Porphobilinogen synthase to give Porphobilinogen (PBG), which contains a pyrrole ring. Four PBGs are then combined through deamination into Hydroxymethyl bilane (HMB), which is hydrolysed to form the circular tetrapyrrole Uroporphyrinogen III. This molecule undergoes a number of further modifications and the main end-product is Protoporphyrin IX. Then Protoporphyrin IX is combined with iron to form heme. One of the best-known porphyrins is heme, the pigment in red blood cells, a cofactor of the protein hemoglobin.
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