Question

Prothrombin, albumin and fibrinogen are synthesised by

• A. Pancreas
• B. Bone marrow
• C. Spleen
• D. Liver

Answer 1

Answer: (D)

Liver

Prothrombin is a component of blood which helps in blood coagulation. It is mainly synthesized by the liver. Prothrombin of blood plasma is converted to thrombin in the presence of thromboplastin and calcium ion during blood clotting. Albumin is a globular protein, produced by the liver. It occurs in blood plasma and is the most abundant blood protein in mammals. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones in the blood and plays a major role in stabilizing extracellular fluid volume by contributing to oncotic pressure.
Fibrinogens are large, soluble and complex glycoproteins in vertebrates, that helps in the formation of blood clots. It is synthesized in the liver by the hepatocytes. The fibrinogen molecule is converted by thrombin into fibrin during blood clot formation

So, the correct answer is 'Liver'