We know that any positive integer ending with the digit zero is divisible by 5 and so its prime factorization must contain the prime 5
We have
4n=22n
⇒ The only prime in the factorization of 4n is 2.
⇒ There is no other primes in the factorization of 4n=22n
[By uniqueness of the Fundamental theorem of Arithmetic]
⇒ 5 does not occur in the prime factorization of 4n for any n.
⇒ 4n does not end with the digit zero for any natural n.