Pthalamide on treatment with ethanolic potassium hydroxide forms potassium salt of phthalimide which on heating with alkyl halide followed by alkaline hydrolysis produces the corresponding amine. This reaction is known as:

Gabriel phthalimide synthesis

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Stephen reaction

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Etard reaction

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Hoffmann bromamide reaction

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Solution

The correct option is A
Gabriel phthalimide synthesis

Pthalamide on treatment with ethanolic potassium hydroxide forms potassium salt of phthalimide which on heating with alkyl halide followed by alkaline hydrolysis produces the corresponding amine. This reaction is known as Gabriel phthalimide synthesis reaction.

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Similar questions

Write short notes on the following:

(i) Carbylamine reaction

(ii) Diazotization

(iii) Hofmann's bromamide reaction

(iv) Coupling reaction

(v) Ammonolysis

(vi) Acetylation

(vii) Gabriel phthalimide synthesis.

The following dihaloalkanes gives an N-(haloalkyl)phthalimide on reaction with one equivalent of the potassium salt of phthalimide. Deduce the structure of the phthalimide derivative formed:

Q. (a) Write the reactions involved in the following:

(i) Hoffmann bromamide degradation reaction

(ii) Diazotisation

(iii) Gabriel phthalimide synthesis

(b) Give reasons :

(i)

(C H_{3})_{2} N H

is more basic than

(C H_{3})_{3} N

in an aqueous solution.

(ii) Aromatic diazonium salts are more stable than aliphatic diazonium salts.

Q. Which of the following amines cannot be prepared by Gabriel phthalimide reaction?

Q. Assertion :Gabriel phthalimide rection can be used to prepare aryl amines Reason: Aryl halides have same reactivity as alkyl halids towards nucleophilic substitution reactions.

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