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Question

Pyruvate, which is formed by the glycolytic catabolism of carbohydrates in the cytosol, after it enters mitochondrial matrix, undergoes

A
oxidative carboxylation
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B
oxidative decarboxylation
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C
reductive carboxylation
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D
carboxylation
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Solution

The correct option is B oxidative decarboxylation
Glycolysis is the process in which one glucose molecule is broken down to form two molecules of pyruvate.
Glycolysis takes place in the cytoplasm of a cell as the first step in cellular respiration.
If oxygen is available, aerobic respiration will go forward.
In eukaryotic cells, the pyruvate molecules produced at the end of glycolysis are transported into mitochondria. Before that pyruvate decarboxylation or pyruvate oxidation, also known as the link reaction (or oxidative decarboxylation of pyruvate), occurs, which is the conversion of pyruvate into acetyl-CoA by the enzyme complex pyruvate dehydrogenase complex.

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