Rank (faster to slowest) the following carboxylic acid derivatives in terms of their reactivity towards nucleophile :

(I) acetamide

(II)acetyl chloride
(III) methyl acetate

(IV) acetic anhydride

I I > I V > I I I > I

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I > I I I > I V > I I

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I I > I I I > I V > I

No worries! We‘ve got your back. Try BYJU‘S free classes today!

I > I V > I I I > I I

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Solution

The correct option is C $I I > I V > I I I > I$
Acid chloride is the most reactive acid derivative while acid amide is most stable acid derivative towards nucleophilic substitution reaction so order is
$a c y l c h l o r i d e > a n h y d r i d e > t h i o e s t e r > e s t e r = c a r b o x y l i c a c i d > a m i d e > c a r b o x y l a t e$

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