The correct option is B The amount of carbon dioxide present in the blood
The level of CO2 in the blood is the most important influence on the regulation of ventilation. The blood level of CO2 acts directly on the respiratory centres in the medulla. A rise in PCO2 (a condition called hypercapnia) decreases the pH level of cerebrospinal fluid. This excites the central chemoreceptors resulting in an increase in the depth and rate of respiration, a condition called hyperventilation.